Recent developments on ultrasound-assisted one-pot multicomponent synthesis of biologically relevant heterocycles

Chemoenzymatic Synthesis of Biologically Relevant Heterocycles

Ultrasound Assisted One-pot Synthesis of Dihydropyrimidinones Using Holmium Chloride As Catalyst

A simple and green chemical procedure was reported for the synthesis of dihydropyrimidinones from various aldehydes, ethyl acetoacetate and urea or thiourea using  holmium chloride as catalyst. The reactions were performed under solvent free conditions with ultrasound irradiation as the energy source. The advantages of this protocol include the excellent yield, operational simplicity, short tim...

New processes for the synthesis of biologically relevant heterocycles*

This article describes the utility of certain readily accessible, ring-fused gem-dihalogenocyclopropanes as building blocks for the synthesis of heterocyclic and biologically active compounds.

A straightforward one-pot multicomponent synthesis of polysubstituted pyrroles.

Polysubstituted pyrroles were efficiently synthesized in moderate yields by a one-pot multicomponent reaction starting from primary amines, ethyl glyoxalate and 2-bromoacetophenones in the presence of pyridine in refluxing acetonitrile. This methodology was utilized to synthesize a highly substituted benz[g]indole.

One-pot chemoenzymatic multicomponent synthesis of thiazole derivatives.

A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions. The blank and control experiments reveal that trypsin from porcine pancreas (PPT) displayed great catalytic activity to promote this reaction and showed a wide tolerance range towards d...